Clinical Trial Confirms Nasal Spray Efficacy In Treating, Reducing Transmission Of Covid-19

In July last year, Glenmark and SaNOtize signed an exclusive long term strategic collaboration for producing, marketing and supplying NONS to treat Covid-19 in India and various other Asian markets. VirX Nitric Oxide Spray is effective in protecting you against all types of viruses and contaminants (bacteria, dust, foreign particles) present on the nasal mucosa. The molecule also has several MOA in single-celled organisms, including DNA damage and inhibition of DNA repair, as well as lipid damage via lipid peroxidation, among others. A nurse or other trained health professional will give your baby this medicine in a hospital. This is a good thing, so you don't want to mess with your microbiome unless you need to. VANCOUVER, British Columbia, May 11, 2022--(BUSINESS WIRE)--SaNOtize Research and Development ("SaNOtize") today announced results from a retrospective clinical study assessing the efficacy of nitric oxide releasing nasal spray (NONS™) in preventing COVID-19 infection after high-risk exposure. Others are working on user-friendly methods to deliver NO topically. Apply 2-3 times daily (2 sprays per nostril during each use), before and after suspected exposure to viruses in high-risk environments (public transportation, days cares, health care settings, shopping centers, sports events, etc. Unusual bleeding or bruising. Israel, New Zealand OK sale of nasal spray that could prevent COVID-19 transmission. NONS is also approved and being sold in Israel and Bahrain, under the name enovidTM. People with COVID infections using the spray also were more likely to have no symptoms at the end of the 16 days study.

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The instructions say to use 2 sprays per nostril, but I just used 1 spray. Nitric oxide has been used medically for years and is known to be safe, but this new use has had some challenges in getting regulatory approval. It has proven anti-microbial properties with a direct virucidal effect on SARS-CoV-2. NO has also been used to treat viral lung infections in people with cystic fibrosis. "We are thrilled to embark on these new partnerships, as they empower SaNOtize to accelerate its research program in various therapeutic fields and expand our Phase 3 NONS COVID-19 trial to additional countries, " said Gilly Regev, PhD, SaNOtize Co-Founder and CEO. London - Brent Research Ethics Committee. After confirmed exposure to COVID-19, infection rate in participants (n=625) who took NONS™ was 6. Against coronaviruses, these include blockage of entry into nasal passage cells and inactivation of the virus via conformation changes to the spike proteins and proteases, which lead to rapid reduction in viral load.

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I did find an ongoing study in people with asymptomatic COVID-19, but the results are not yet available. When used as a preventative the nitric oxide nasal spray should be used along with other prevention methods like masks and improving ventilation. Follow us on social: LinkedIn, Twitter. The presence of other medical problems may affect the use of this medicine. Unfortunately, the kind of study needed to show effectiveness at preventing the disease is extremely large and expensive. Following treatment with the nasal spray, patients had no adverse events during the UK trial, which corresponds with the results from earlier Canadian clinical trials that assessed results from more than 7000 self-administered treatments of the nasal spray by patients. This randomized, double-blind phase 3 clinical trial evaluated a seven-day treatment of NONS plus standard of care versus placebo nasal spray plus standard care in patients with symptomatic COVID-19. NONS when sprayed over nasal mucosa acts as a physical and chemical barrier against the virus, preventing it from incubating and spreading to the lungs. Viral load was reduced by 93. NONS Reduces Infection Rate After Exposure to COVID?

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The infected roommates had Delta and Omicron variants in almost a 50/50 split and there was no difference seen based on which variant it was. Again, using masks, isolating and improving ventilation should also be used to reduce the spread. You can also use it when you start to get symptoms but the studies were not super impressive in NONS reducing COVID symptoms. That would be very exciting. For a lot of people infected by COVID-19, they exhibit mild symptoms: dry cough, mild fever, tiredness, loss of smell. For the treatment of adult patients suffering from Covid-19, pharma company Glenmark has launched Nitric Oxide Nasal Spray (FabiSpray) in India. For best results, it is suggested to avoid other immediate use of nasal sprays or similar treatments, for at least 30 minutes after using VirX. Your baby's doctor will measure how much methemoglobin is in your baby's blood while receiving this medicine. Yes, nitric oxide (NO) is safe. Getting your booster, choosing wisely whether to go maskless, and avoiding large crowds remains the best way of not getting sick. For more information, visit Contacts. The amount of nitric oxide from NONS is not enough to be absorbed systemically (bioavailability is nil) nor inhaled during NONS administration. It is a topical, non-systemic, liquid nasal spray in Hong Kong made out of a readily available compound that is used extensively in food. "SaNOtize is excited to collaborate with Glenmark in providing broader, easier and affordable access to its treatment.

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We all have a microbiome in our nasal passage, when we are healthy we have a good balance of healthy bacteria. FabiSpray has been designed to destroy the SARS-CoV-2 virus that causes Covid-19 in the upper airways. It was easy to use, I felt a tiny bit of burning but it was fine. It is based on nitric oxide, which has proven anti-microbial properties and a direct effect on SARS-CoV-2. This therapy has the potential to make a crucial contribution to COVID-19 management, with its ease of use in the current highly transmissible phase of pandemic, " said Dr. Monika Tandon, Senior VP & Head - Clinical Development, Glenmark Pharmaceuticals Ltd. "Given the rate at which COVID-19 continues to mutate, and the consensus that it will soon be endemic, we need to expand the tools at our disposal to protect against it, " said Chris Miller, PhD, Chief Scientific Officer and co-founder of SaNOtize. Although initial data is promising, this study will help clarify the effects and potential of nitric oxide in COVID-19 treatment. It does not cause drowsiness. Do not take other medicines unless they have been discussed with your doctor. This reaffirms our commitment to providing yet another safe and effective antiviral treatment for COVID-19, and we are confident it will offer patients a much needed and timely therapy option, "Robert Crockart, chief commercial officer, Glenmark Pharmaceuticals Ltd. said. Our son doesn't like it, although he tolerates it.. This might sound odd, since we've had face masks since early in the pandemic, then mRNA vaccines that are highly effective against serious illness and death, and now Paxlovid as an oral antiviral medication to be taken within five days of developing symptoms. In New Zealand, SaNOtize has registered its nasal spray with the New Zealand Medicines and Medical Devices Safety Authority, which permits the company to distribute and sell NONS over the counter immediately, the Vancouver-based company said. The enovid spray has these ingredients: - Sodium Choride.

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A central lesson might be that we need to move away from the idea of managing a single "bug" with a single tool – it will take a collection of approaches working in concert to fully wrap our arms around a given problem. In some countries, Enovid is sold under the brand name Virx. NONS for COVID-19 Treatment [COVID-19]. A commonly used thickening agent in eye drops and lubricants. So it is probably worth killing our nasal microbiome if it means we stop COVID from infecting us or we can reduce the infection. Additionally, the pharmacology, toxicity, and safety data for NO use in humans has been known for decades, which has allowed it to be a safe treatment method for use in newborn babies as well as adults.

Of these, 203 participants used NONS at least four times per day and 422 volunteers did not use NONS. In February, SaNOtize announced that its nasal spray product was approved for sale in India after said trials proved it can reduce viral load in people with mild cases of coronavirus. To continue, please click the box below to let us know you're not a robot. Each sprayer contains 25ml, around 200 doses of spray (about a month's supply).

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Please refer to user instructions). This will allow the doctor to see if the medicine is working properly and to decide if your baby should continue to receive it. SOURCE Glenmark Pharmaceuticals Ltd.