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An experimental study on the effect of Xuefu Zhuyu pills on activating qi and removing blood stasis. The XFZY will be manufactured by Jilin Aodong Yanbian Pharmaceutical Co. Ltd. (Jilin Province, China) according to the requirements of the Good Manufacturing Practice (GMP). To further profile the combined effects of XFZYT, all targets that interacted with CFCG in XFZYT were enriched by GO enrichment analysis (Fig. A systematic review found that Xuefu Zhuyu (XFZY) has a promising effect on PD management, yet there is a dearth of high-quality evidence in support of this claim. Our shop contains xue fu zhu yu wan from the following manufacturers: For many reasons such as availability, ecological choices, and/or price, each manufacturer or herbalist may well adjust the exact composition of a specific formula. Xue Fu Zhu Yu Wan, Herbal Times®. Found that ESR2 was significantly related to the risk of stroke [41]. For example, leukocyte activation involved in inflammatory responses (GO:0, 002, 758), the production of molecular mediators involved in inflammatory responses (GO:0, 070, 498), and inflammatory responses to antigen stimulation (GO:0, 031, 349).

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Wang, L. S., Zhang, Y. Q., Feng, Z., Ying, X. W., Wang, X. J., & Huo, X. L. (2017). Clinical study on primary dysmenorrhea treated with combination of traditional Chinese medicine and Western medicine. Chinese Journal of Pharmaceutical Analysis(12), 2208–2212. Choking sensation when drinking. Xue fu zhu yu wan while trying to conceive?. Interpretation in the update of Chinese guidelines for diagnosis and treatment of acute intracerebral hemorrhage 2019. The primary outcome will be the mean change in pain intensity as measured by VAS, while the change in menstrual pain duration, the change in peak pain intensity as measured by VAS, the Cox Menstrual Symptom Scale (CMSS), quality of life EQ-5D-5L, cumulative painkiller consumption, and health economics will be included as secondary outcomes.

Experimental study of Xuefu Zhuyu decoction in activating blood and removing blood stasis. The above results demonstrated that acacetin, quercetin and luteolin possessed protect effect in hypoxia treated HT22 cells. Therefore, how to promote hematoma absorption as soon as possible and reduce edema around the blood clots are a difficult point in conservative treatment. CFDA: China Food and Drug Administration. Blue Poppy Enterprises, Inc. Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage | BMC Complementary Medicine and Therapies | Full Text. All rights reserved. The higher the percentage, the higher the reliability and accuracy of the model. ClusterProfiler: an R package for comparing biological themes among gene clusters.

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There are n nodes in the network. 11%, respectively, which confirmed the reliability and accuracy of the effective compound group optimization and mechanism speculation strategy proposed by us. Chronic incessant hiccups. The mechanism of CCG was deduced by using the target protein response score(TPRS) model. A total of 716 compounds were found in XFZYD through systematic search of the compounds in the published database of 11 herbs. Xue Fu Zhu Yu Tang- 血府逐瘀湯- Drive Out Stasis In The Mansion Of Blood Decoction. There are three kinds of effective proteins in the effective space. Extreme mood swings. The dose may be doubled for a quicker and stronger response as needed (e. g., in an acute phase). Xu X, Wang W, Xi W, et al. Orifices, dredges and opens channels, and collaterals, resolves chest. Contraindicated for those with active hemorrhage disorders. Spider naevi on the cheeks, nose, trunk, inner knee and ankle.

Miscellaneous Patents. They contain no additives, artificial colors or sugar. A Novel Network Pharmacology Strategy to Decode Mechanism of Lang Chuang Wan in Treating Systemic Lupus Erythematosus. Xue fu zhu yu wan asia link. Dysmenorrhea can be classified into primary dysmenorrhea (PD) and secondary dysmenorrhea, with the former more prevalent in young women [2]. 4804 SE 69th Avenue. The use of a placebo has the advantage of preventing expectation biases resulting from inadequate blinding.

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Morán J, Perez-Basterrechea M, Garrido P, Díaz E, Alonso A, Otero J, Colado E, González C. Effects of Estrogen and Phytoestrogen Treatment on an In Vitro Model of Recurrent Stroke on HT22 Neuronal Cell Line. Outcome measurement time points are provided in Table 2. Prostatic hypertrophy. We believe that this research will provide important evidence regarding the use of XFZY to treat dysmenorrhea. In a previous trial, the mean change for VAS in the placebo group was 0. Xiao L, Yancang D, Yajing S, et al. If these two results are inconsistent, the ITT analysis will be considered the primary result. Some other trials also found XFZY had a better response rate for PD as compared to conventional medication (e. g., diclofenac sodium, ibuprofen) with head-to-head comparison [23, 24, 25] or add-on design [26, 27]. Primary dysmenorrhea. Adverse events will also be reported. Guang Ci Tang products are manufactured in a GMP certified facility and production strictly follows the principle of "authentic materials, traditional preparation, and scientific process". Under no circumstances does. Xue fu zhu yu wan ting. Found that ACER2 was involved in sphingomyelin metabolism, which could catalyze ceramide hydrolysis to produce sphingosine, and sphingosine was further phosphorylated to produce sphingosine monophosphate [40]. Construction and analysis of c-t network.

TCMInfoline – Archived. CCG: Key group of effective compounds. GPHCM: Guangdong Provincial Hospital of Chinese Medicine. Activation of AKT can induce the phosphorylation of lipid substrate and can promote downstream protein kinase B, which can contribute to cell proliferation and differentiation [45]. Stress Relief & Sleep. The main methods in treating ICH include drug therapy, surgical treatment, etc. The placebo's primary ingredients are honey, white granulated sugar, fried brown sugar, bitterants, ginseng essence, natural edible pigments, and food antiseptic. Determination of Nucleosides Compounds in Walnut Kernel from 10 Different Regions. Cell viability assay. Function analysis of CCG targets. HT22 cells (6 × 104 cells/well) were plated in 96-well plates for 24 h, then the cells were exposed to OGD model with hypoxia for 12 h, followed by treatment with 40, 80, 120, 160 and 200 μM acacetin, quercetin, and luteolin, respectively. All compounds of XFZYD were derived from three public herb medical data sources, TCMSP database [14], TCM integrated database [15] and TCM database@Taiwan [16]. Aspects of the reliability and validity of the visual analogue scale. Investigators will evaluate the subjects' CM syndrome at baseline and each visit.

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Directs the actions of the formula to the upper body. Are not meant to treat, cure or prevent disease. For example, a randomized clinical trial (RCT) [22] found that XFZY had a higher cured rate and a lower recurrence rate compared with indomethacin for PD. With Tao Ren and Hong Hua, for symptoms associated with Blood Stasis. It will be conducted in 6 university hospitals in different Chinese provinces. Participants will self-rate their mean pain intensity using VAS at baseline and each visit. The primary outcome is change in the mean pain intensity as measured by the visual analog scale (VAS), from baseline to the end of treatment. Post-stroke recovery when stasis is from qi and yang deficiency - post-stroke symptoms, paralysis, atrophy of the limbs, drooling, slurred speech, etc. XFZYD composed of these herbs has the effects of eliminating edema and improving local circulation, so it is widely used in the treatment of ICH. Hand-Painted Scrolls. Formulas may be used alone, in combinations, and/or in stages. ChiCTR1900026819) on 23 October 2019.

Constructing and analyzing weighted pathogenic gene–gene interaction network is the foundation in understanding the pathogenesis of ICH and can provide intervention strategies. Sichuan Tradit Chinese Med. Most of the herbs in the formula have shown some anti-cancer properties in studies (human or animal)…. The results show that the optimization strategy of CHM prescription combining optimization space with CI model is reliable, and the predicted CCG may play a therapeutic role by mediating various related ways. With Hong Hua and Chuan Xiong, invigorates Blood and dispels Stagnation, especially in the upper body. Here, a novel integrated pharmacology module was designed to predict the CCG and depict the underlying mechanisms of XFZYD on ICH (Fig. You should consult the laws of any jurisdiction when a transaction involves international parties. In addition to complying with OFAC and applicable local laws, Etsy members should be aware that other countries may have their own trade restrictions and that certain items may not be allowed for export or import under international laws. Products are food supplements. There are many topological properties that can be used to describe the network, among which the degree is one of the indicators to describe the importance of nodes in the network. Effect of Xuefu Zhuyu Decoction on Secretion of VEGF and PDGF in Human Umbilical Vein Endothelial Cells. Butyl-phthalide is a potential active compound of XFZYD.

CENTRAL SOUTH PHARMACY(05), 329–331. For example, Buyang Huanwu Decoction can alleviate brain edema after ICH, reverse blood–brain barrier (BBB) damage and reduce nerve function damage [3]. In order to protect our community and marketplace, Etsy takes steps to ensure compliance with sanctions programs. 5 to Part 746 under the Federal Register.