Biomedicines | Free Full-Text | Low-Molecular-Weight Β-1,3-1,6-Glucan Derived From Aureobasidium Pullulans Exhibits Anticancer Activity By Inducing Apoptosis In Colorectal Cancer Cells

Kanda, Y. ; Ohata, H. ; Sakai, H. ; Mori, Y. ; Shiokawa, D. ; Yokoi, A. ; Owa, T. ; Ochiai, A. ; Okamoto, K. NF-κB Suppression Synergizes with E7386, an Inhibitor of CBP/β-Catenin Interaction, to Block Proliferation of Patient-Derived Colon Cancer Spheroids. Measurement of Apoptotic Cells. Multi-Caspase Assay. Cells and Cell Viability Assay. Gupta, S. ; Prasad, S. ; Sethumadhavan, D. ; Nair, M. ; Mo, Y. ; Aggarwal, B. Parzonko, A. New concept chapter 3. ; Makarewicz-Wujec, M. ; Jaszewska, E. ; Harasym., J. ; Kozłowska-Wojciechowska, M. Pro-apoptotic properties of (1, 3)(1, 4)-β-D-glucan from Avena sativa on human melanoma HTB-140 cells in vitro. Schiavone, M. ; Vax, A. ; Formosa, C. ; Martin-Yken, H. ; Dague, E. ; François, J. M. A Combined Chemical and Enzymatic Method to Determine Quantitatively The Polysaccharide Components in The Cell Wall of Yeasts.

• Concept development in design
• What is a concept development
• New concept chapter 1
• New concept chapter 3

Concept Development In Design

Sun, M. ; Chen, X. ; Han, M. ; Yang, Y. N. ; Gao, X. ; Ma, X. ; Huang, Y. ; Li, X. ; Gai, M. T. ; Liu, F. ; et al. Molecules 2022, 27, 8083. Tsujimoto, Y. ; Shimizu, S. Bcl-2 Family: Life-or-Death Switch. Umar, S. ; Sarkar, S. ; Cowey, S. ; Singh, P. Activation of NF-κB Is Required for Mediating Proliferative and Antiapoptotic Effects of Progastrin on Proximal Colonic Crypts of Mice, In Vivo. Shamas-Din, A. Concept development in design. ; Kale, J. ; Leber, B. ; Andrews, D. Mechanisms of Action of Bcl-2 Family Proteins. 2014, 34, 3329–3335. Anticancer Agents Med. Cells 2022, 11, 502. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Hayashi, N. ; Shoubayashi, Y. ; Fukudome, K. Hydrothermal processing of β-glucan from Aureobasidium pullulans produces a low molecular weight reagent that regulates inflammatory responses induced by TLR ligands.

What Is A Concept Development

LMW-AP-FBG Reduces Viability of CT-26 Colon Cancer Cells. Weng, W. ; Feng, J. ; Qin, H. ; Ma, Y. Molecular Therapy of Colorectal Cancer: Progress and Future Directions. Kim JH, Seo J, No H, Kuge T, Mori T, Kimoto H, Kim J-K. Biomedicines. Materials and Methods. 2006, 26, 4131–4141. Soleimani, A. ; Rahmani, F. ; Ferns, G. ; Ryzhikov, M. ; Avan, A. ; Hassanian, S. Role of The NF-κB Signaling Pathway in The Pathogenesis of Colorectal Cancer. Greten, F. ; Grivennikov, S. I. Inflammation and Cancer: Triggers, Mechanisms, and Consequences. Nam, S. Tussilagone Reduces Tumorigenesis by Diminishing Inflammation in Experimental Colitis-Associated Colon Cancer. Oana, C. ; Adriana, T. ; Mircea, C. New concept chapter 1. ; Dragos, S. ; Monica, H. Natural Macromolecules with Protective and Antitumor Activity. Kim, Ji Hyeon, Jeonghyeon Seo, Huiwon No, Takao Kuge, Takahiro Mori, Hisashi Kimoto, and Jin-Kyung Kim.

New Concept Chapter 1

Bakshi, H. ; Quinn, G. ; Nasef, M. ; Mishra, V. ; Aljabali, A. ; El-Tanani, M. ; Serrano-Aroca, Á. ; Webba Da Silva, M. ; McCarron, P. ; Tambuwala, M. Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-κB/VEGF Pathways. Tada, R. ; Tanioka, A. ; Iwasawa, H. ; Hatashima, K. ; Shoji, Y. ; Ishibashi, K. ; Adachi, Y. ; Yamazaki, M. Structural Characterization and Biological Activities of a Unique Type β-D-Glucan Obtained from Aureobasidium pullulans. Sun, X. ; Ng, T. ; Sham, K. ; Zhang, L. ; Chan, M. V. ; Wu, W. ; Cheng, C. Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer. Chao, T. ; Chang, G. ; Chen, W. Y. ; Chen, P. ; Mao, F. The Synergistic Effect of Rapamycin Combined with 5-Fluorouracil in BALB/c Mice Bearing CT-26 Tumor Cells. Nutrients 2021, 13, 242.

New Concept Chapter 3

Suzuki, T. ; Kusano, K. ; Kondo, N. ; Nishikawa, K. ; Kuge, T. ; Ohno, N. Biological Activity of High-Purity β-1, 3-1, 6-Glucan Derived from The Black Yeast Aureobasidium pullulans: A Literature Review. LMW-AP-FBG Induces Apoptosis in CT-26 Cells. Western Blot Analysis. Vaideeswar, P. ; Kundu, S. ; Singaravel, S. ; Tyagi, S. Spontaneous Aortic Rupture: Report of Two Cases with Review of Literature. Goodridge, H. ; Wolf, A. ; Underhill, D. Beta-glucan recognition by the innate immune system. Tsoni, S. ; Brown, G. D. Beta-Glucans and dectin-1. LMW-AP-FBG Reduces Growth of Syngeneic Transplanted CT-26 Tumors in Mice. 2011, 404, 1105–1110. Biomedicines 2023, 11, 529.

Fantini, M. C. ; Guadagni, I. B. Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing The Proinflammatory Microenvironment. Google Scholar] [CrossRef][Green Version]. Author Contributions. Biology 2021, 10, 854. Zhang, S. ; Liu, Y. ; Xiang, D. ; Yang, J. ; Liu, D. ; Ren, X. ; Zhang, C. Assessment of Dose-Response Relationship of 5-Fluorouracil to Murine Intestinal Injury. PLoS ONE 2015, 10, e0124809. Kimura, Y. ; Sumiyoshi, M. ; Suzuki, T. ; Sakanaka, M. Antitumor and Antimetastatic Activity of a Novel Water-Soluble Low Molecular Weight Beta-1, 3-D-Glucan (Branch Beta-1, 6) Isolated from Aureobasidium pullulans 1A1 Strain Black Yeast.